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19 Lipids - Storage and Transport

19 Lipids - Storage and Transport - Lipid transport and...

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Lipid transport and storage HNFE 3025 Fall 2009 1
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Lipoproteins Composed of lipids and proteins Important role in lipid transport Implicated in cardiovascular disease Protein portion is called apolipoprotein Important structurally and functionally One or more in each lipoprotein Have a role in signaling and recognition Can be used to evaluate potential cardiovascular risk 2
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Fig. 5-13, p. 144 3
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Lipoproteins Chylomicrons are lipoproteins and transport exogenous dietary lipids Other types transport endogenous lipids Very low density lipoprotein (VLDL) Intermediary lipoprotein (IDL) Low density lipoprotein (LDL) High density lipoprotein (HDL) Different types differ in lipid composition, apolipoprotein composition, physical properties, and metabolic function 4
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Fig. 5-14, p. 145 5
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Complex Source Density (g/ml) Chylomicron Intestine <0.95 VLDL Liver 0.95-1.006 IDL VLDL 1.006-1.019 LDL VLDL 1.019-1.063 *HDL 2 Intestine, liver (chylomicrons and VLDLs) 1.063-1.125 *HDL 3 Intestine, liver (chylomicrons and VLDLs) 1.125-1.21 Albumin-FFA Adipose tissue >1.281 Lipoproteins 6
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Apolipoproteins Stabilize lipoproteins as they circulate in the aqueous environment of the blood Confer specificity on the specific lipoprotein complexes Allows recognition by specific receptors on cell surfaces Divided into subclasses denoted by letter A to E Abbreviated Apo 7
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Table 5-4, p. 146 8
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Re-formed lipid derived from dietary sources Least dense and largest of lipoproteins Made in and secreted from intestinal cells Composed of 82-85% TAG and some chlesterol and cholesterol esters Delivers lipids to tissues other than liver, primarily muscle and adipose tissue 9 Chylomicrons
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Chylomicrons Three types of chylomicrons Nascent chylomicrons
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