25 Lipids - Metabolic Dysregulation

25 Lipids - Metabolic Dysregulation - Metabolic...

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Metabolic Dysregulation HNFE 3025 Fall 2009
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Metabolic Syndrome An example of the interplay between nutrient intake and metabolism Refers to a cluster of risk factors for cardiovascular disease Syndrome includes: Insulin resistance or glucose intolerance Hypertension Dyslipidemia Central obesity Hyperleptinemia Hyperuricemia Why call it a syndrome? - Not a disease but a set of symptoms Not all symptoms must be present to make diagnosis - debatable American Heart Association - 3 of 5 any five symptoms must be present to diagnose American Diabetes Association – Doubt the benefit of diagnosing metabolic syndrome Perhaps more important to focus on individual risk factors 2
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Table 7-3, p. 264 3
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Insulin Resistance The defect that ties all symptoms of metabolic syndrome together Characterized by hyperinsulinemia Result of pancreas releasing more insulin to maintain euglycemia Ultimately can result in hyperglycemia Primarily seen in muscle, adipose tissue, and liver Muscle – insulin loses its ability to stimulate glucose uptake Adipose tissue – insulin no longer suppresses lipolysis Liver – insulin no longer suppresses 4
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Insulin Resistance Insulin resistance in these tissues explain elevated blood glucose and free fatty acid levels There is a paradox Some insulin pathways are resistant to insulin while others are not Glucose uptake, lipolysis and gluconeogenesis are resistant Lipogenic pathways retain sensitivity Increased TAG synthesis – muscle, adipose, and liver
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This note was uploaded on 03/23/2010 for the course HNFE 3025 taught by Professor Mwhulver during the Spring '10 term at Virginia Tech.

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25 Lipids - Metabolic Dysregulation - Metabolic...

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