lecture_2

lecture_2 - BIOCHEMCIAL PROCESSING OVERVIEW CHARLES L...

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BIOCHEMCIAL PROCESSING: OVERVIEW CHARLES L. COONEY DOWNSTREAM PROCESSING COURSE MIT Professional Institute August 1-4, 2005
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THE CHALLENGE OF DOWNSTREAM It is difficult to efficiently and economically recover a high purity biochemical product from a complex mixture of related and functional molecules, impurities and contaminants which have similar physical and chemical properties.
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YOUR GOAL IF YOU DON’T KNOW WHERE YOU ARE GOING AND YOU DON’T HAVE A MEANS OF MEASURING WHERE YOU ARE THEN YOU WON’T KNOW WHEN YOU ARRIVE Ama Dablam 22,275 ft
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THE DIVERSE BIOCHEMICAL PROCESS INDUSTRY PRODUCTS AND SERVICES FOR MULTIPLE MARKETS Health Care Therapeutics Diagnostics Device Specialty Chemical Commodity Chemicals Waste Treatment MANUFACTURING BY MULTIPLE TECHNOLOGIES Biosynthetic - Microbial, Animal, Plant Extractive – Animal, Plant Chemical Synthesis
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THE DIVERSE BIOCHEMICAL PROCESS INDUSTRY (Continued) PRODUCTS BELONG TO MULTIPLE CLASSES Small Molecules –P r o t e i n s Nucleic Acids Carbohydrates
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Where is the Leverage? Relationship of Profit to Price PROFIT = VF M ( S P S A C M ) Selling price is Fixed by utility And competition Manufacturing cost Specific Activity of Product Market share is a function of proprietary position: Patents Marketing Distribution Innovation speed Market size determined by problem solved S a S p C m Profit (Units/lb) ($/unit) ($/lb) $ MM 200 0.45 55 210 200 0.45 35 330 200 0.35 55 90 500 0.45 55 1020 2000 0.45 55 5070 Sensitivity of Profit to S p , S p m V= 30 b lb sugar & Fm = 0.2
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POINTS TO CONSIDER IN DOWNSTREAM PROCESSING DSP begins with Raw Material selection “Garbage in means garbage out” There are trade offs, e.g. between purity and yield “No Free lunch” Mass and Energy are conserved, “What goes in must
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lecture_2 - BIOCHEMCIAL PROCESSING OVERVIEW CHARLES L...

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