Session 11 (DNA Structure and Replication)

Session 11 (DNA Structure and Replication) - MCB 181 Study...

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MCB 181 Study Session 11 (DNA Structure and Replication)
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Learning Goals for Study Session 11 (DNA Structure and Replication) Be able to describe the relationship between a sequence of nucleotides in DNA and a gene. Briefly describe the scientific findings that lead to the determination of the structure of DNA. Describe the key features of the three dimensional structure of DNA and indicate how its structure facilitates the process of replication. Distinguish between origin of replication and replication fork as related to semiconservative DNA replication. Be able to describe two surprising limitation of DNA polymerase and indicate how they are overcome during the replication process. Briefly describes the roles of primase, polymerase, helicase, and ligase during DNA replication. Be able to describe telomeres and there importance in DNA replication and cell division. Briefly discuss the importance of proofreading and DNA repair in successful replication of DNA.
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DNA (d eoxyribon ucleic a cid) is the genetic material! A gene is a sequence of nucleotides in DNA that controls the expression of a trait. There are thousands of different genes in an organism’s genome , the sum total of the genes in the haploid number of chromosomes. The sequence of nucleotides in genes is transcribed and translated to produce the primary amino acid sequence of the thousands of proteins that lead to an organism’s phenotype. In this study session we consider the structure of the DNA molecule and how the molecule is replicated during the S phase of the cell cycle prior to cell division. In Study Session 12, we consider how the information in genes is used to synthesize proteins.
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A DNA molecule consists of two polynucleotide strands running in opposite (antiparallel) directions and held together by hydrogen bonds between complementary bases! Recall from Study Session 3 that DNA is composed of nucleotides linked to one another by covalent bonds between the phosphate group and pentose sugars. The nitrogenous bases in DNA are adenine
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This note was uploaded on 03/24/2010 for the course MCB 181 taught by Professor Jorstad during the Spring '07 term at University of Arizona- Tucson.

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Session 11 (DNA Structure and Replication) - MCB 181 Study...

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