201-L37-actionponent-2009ND slides

201-L37-actionponent-2009ND slides - 1. Describe the normal...

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Unformatted text preview: 1. Describe the normal concentration gradients for Na + and K + that exist across the membrane of all cells. 2. Predict what will happen to the cell membrane potential (PD) if permeability of the membrane increases or decreases for either Na + or K + . Review Basis of Bioelectric Behavior 1. Maintain large, stable Na + and K + gradients 2. Manipulate permeability of the membrane to Na + and K + Manipulation of Membrane Permeability Ion Channels 1. Integral membrane proteins 2. Channels can be open or closed 3. Some channels are routinely open e.g., K-leak channel is the basis of the inside-negative resting PD 4. Some channels have their open states regulated a. Voltage-gated channels open when PD gets less negative depolarized b. Chemically (ligand )-gated channels open when a signal molecule binds to the channel protein (e.g., ACh) c. Mechanically-gated channels open when membrane gets stretched (and some channels are physiologically regulated in other ways...) Graded Potentials Occur in dendrites and cell body of neuron Size varies with strength of stimulus Neuronal Action Potential...
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This note was uploaded on 03/24/2010 for the course PSIO 201 taught by Professor Stanescu during the Spring '08 term at University of Arizona- Tucson.

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201-L37-actionponent-2009ND slides - 1. Describe the normal...

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