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Unformatted text preview: Ca++ pump in SR no longer removes Ca++ 2 Nov 1112:26 PM Cells Cells contain actin, soluble and fiber forms Cells contain myosin (cytoplasmic myosin) allows cellular shape change and motility. Look at Smooth muscle. Actin and Myosin Myosin Light Chain in smooth muscle, the MLC, controls the access of the myosin to actin. Ability of MLC to interact with actin depends on its phosphorylation state. In order for smooth muscle to contract, it is necessary for MLC to be phosphorylated The enzyme that carries this out is Myosin Light Chain Kinase (Kinase is an enzyme that causes phosphorylation) MLCK MLCK is inactive, and needs to be activated in order for the muscle to contract. Activation occurs through binding to a small protein calmodulin. Calmodulin binds Ca++ and is only able to activate MLCK when it has bound Ca++ Nov 1112:41 PM 3 Nov 1011:55 AM...
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- Spring '09
- Physics, Myosin Light Chain, MLCK, Myosin Myosin Light