lecture30 - Intermediate Filaments : 10 nm filaments,...

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Unformatted text preview: Intermediate Filaments : 10 nm filaments, (100A) (microfilaments 8nm, microtubules are 28nm) in Epithelia, ­­ Desmin, desmosomes, Cytokeratins in Fibroblasts ­ Vimentin Nerve Tissue: Neurofilament proteins Glia ­ glial fibrilloacidic protein ­ GFAP Nov 13­12:19 PM Nov 10­12:23 PM 1 IN both smooth and striated muscle, Ca++ play a triggering role. Striated: bind to troponin C ­ molecular movements Smooth: binds to calmodulin ­ enzyme "cascade" Calmodulin and troponin c seem to share a good deal of sequence similarity Ca++ control: Striated Muscle ­ physical association between the sarcotubule system/sarcoplasmic reticulum/fiber smooth muscle ­ several sources ­ plasma membrane, SER, mitochondria hormone receptors in the membrane ­ trigger a series of reactions that cause Ca++ to be released from the SER. In non­muscle cells ­­ actin is present, so is myosin ­ triggered by Ca++ ­ calmodulin. For Cilia, Ca++ cause a change in the beat frequency Nov 13­10:17 AM Cytoskeleton three components: microtubules: cell shape, movement of particles/structures within the cell intermediate filaments ­ structural support microfilaments ­ stress fibers (cells in culture), movement of membranes, cell exterior ­ ruffles, microvilli. Phalloidin ­ inhibitor of f actin. Nov 13­12:30 PM 2 Metabolism How the cell obtains and works with energy. Potential Energy Size Oxidation State High Large Reduced Low Small Oxidized Nov 13­12:38 PM 11/8/2006 12:11 PM 3 11/8/2006 12:11 PM nicotinamide adenine dinucleotide 11/8/2006 12:12 PM 4 Coenzyme A 11/8/2006 12:13 PM 5 ...
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This note was uploaded on 03/24/2010 for the course PHYSICS 2202 taught by Professor Mihalisin during the Spring '09 term at Temple.

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