lecture39 - Cell Cycle Pregrammed Cell Death(Apeptesis...

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Unformatted text preview: Cell Cycle Pregrammed Cell Death (Apeptesis) ptesis D [Li'IS/im DIJH [flit-Far] u stain eell with Feuigen reaetien - quantitative fer DNA There were eells that had the same ameunt ef DNA ether cells that had twice the ameunt ef the first greup seme few cells with DNA ameunts between these. Tn get cells in divide in synchmny - 0113 pnpulafinn in S was fused with calls in G1 Centrel ef the Cell Cycle Mitotic I _ " -.'-- : *_ ' Mitotic Chmstumfl- Pulverized _. . ‘__€firemesemesi chremesn'me ._ .-_- . - ~ - «. fragments ELI] meme amazemzeezéeezea . . r -h'- . . .-:Ehfpme_sqm'es_ _ _ _ _ ' . -”.-. . . .i' -_ .- ' - I a" _- . - -_-\. ""' I 5 F _ - _I -- I I ' .: - ' 'fi I ' h - a. H e 'H—flh tel-and mhularfllnh ,Jh'eflfillilflfi Jail-HUI adrenal ngm 14.3;- ml and “mm" Hflnfl m m 1mg Mm "my ” 5““! Fl 9:! IE? rig-n 1-1-34: tel Ind names Haley! Aime mes HIhn mafia. Suns! Fig 14'3 Different phases ef the eell eyele een eentrel the behevier ef the cell. Mitusis Mitnsis Mitusis w lnterphase lnterphase lnterphase njmsig pmmnfing Fig. 14—4 M _ _ factor QAPF actmty . High Law High Low Figure 1-1-4 Eelland Mulecflar Blulagyflfe 1'1:- IMSJuhn 'nI'ilnayI fl- Sauna] s G; +M G1" I I I G. s «32 M Figure 1-1—5 lI'lell and Muleculnr fliulngy. Ali-E: {El 2H5 John Wiley E Sum! o o Mitosis e lntarphasa [62} lnterphasa (G11 Thrifi1—. urns. T111151 CAK r _. WEE1 (dc: 5 - - Inactiva- - 621 fission Fast-nsltotm yeast cell . fisslnn Inactive Active yeast cells J Degradation Figura 1 +51! Call and Malaculal' Biahgyrflia 11:: ENE Jahn Wiley 3: Sans} Fig 14.6 Cyclin BIA + Cdk1 Figure III-E lI'.‘I!allaI1I:| Hfllflfllil Biology-In IE1 Iii-US JuhnWiIE'y & Sum! Cnntml flf Cell Cycle. chackpnmts . r917 mm 1.14.“; (E. and Hulk ”film if: m HIM Jfl Wilq‘ :1: Sun“ figure 'I I-‘Ifl: Cell and Mule-ml" Bluluhw. uln'u: [lb 1M5 hl‘ln “If E Sum-I Black 1327 Thymus Fig 14—10 Ultraviolet Nucleus lenizing radiatien radiatien X. Chkl GI Ina ctivew 1 Active Cdcifi Cdcii 9 flactive Cdc25 Cell cycle P53 9 a arrest p2! "it: g-Iwnactive "IRMA 1| P21? Adapter Cytoplasm P pretein Cell cycle arrest {14—3—3131 Figure 1-1-9 Cell and Melecuiflr Biulngy'. Illa- [Er-11105 Jehn ‘H'li‘iley E Suns] Apflptflsis Prflgraflnned Cell Death Apaptosis - pragrammad call death Calls dia in a characteristic way. Lass af calls in a devalapmantal pathway Dastrucfifln af damagad calls accampalfiad by DNA braakdawn intn small units FigIm-I: 15-31:. CE!" 31:] Mulemhr Biuluyr, -I-.|'1.- [til 2M5 Jul-In Willa-f fl- Emu] Fig 15 -32 I t | n erna Activatien at preapeptetic Ech-I cellular n- . cl framllmr member: [12.15]u Bacl er Bax] arr-rage ‘i Plasma membrane “4‘: u' {5. .':_{:..:: ..'.;.'._ i.‘ i--"=- "ll athd emains " I I I . . . '- Eytechreme E" + Cytoplasmic factnrs {e.g. A pat-1] THA DD ‘ Precaspase-fl + Pmcaspase-E Initiator caspase-3 W Activated initiater caspase-9 cemplex {Apeptescu me} > Executioner precaspases Executiuner cas ase —* l P * Executioner caspase 1 l IPIIPTIISIS II‘IIFIIIBIB Figure 15-33 Cell and Mulecular Einlnmflie {til Iflflfi JflI'I'II wile-Ira Sans} Figure 15-34 Cell and Mulecder Bielegm He l-fi EDDIE Jul-In Wiley 3: firms} Execution er precas peace (2 i ...
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