Pedigree Analysis Worksheet 06

Pedigree Analysis Worksheet 06 - Pedigree Analysis Pedigree...

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Pedigree Analysis Pedigree: A family tree describing the occurrence of heritable characters in parents and offspring across as many generations as possible. How to read a pedigree: -Males are represented by squares -Females are represented by circles -An individual that has the trait featured in the pedigree will have the circle or square darkened (colored in) . -Individuals who are carriers for the trait (heterozygous) have their circle or square half darkened . -Husband and wives are connected by horizontal lines. -Offspring come off the parents by vertical lines. -Generations are numbered with Roman Numerals. -Individuals with in the generation are individually numbered. Knowing that each offspring receives one allele from each parent, a pedigree can be used to predict the genotype and phenotype of individuals. Some Genetic Disorders Albinism (Autosomal Recessive) About one in every 17,000 people have Albinism. These individuals fail to produce melanin, a photoprotective pigment. While melanin's role in protecting us from ultraviolet light is understood, it also has other important functions in the development of the retina and brain and their interconnection of which we know much less. Albinism is an autosomal recessive trait. Cystic Fibrosis (Autosomal Recessive) The most common lethal genetic disease in the United States is cystic fibrosis, which strikes one out of every 2500 whites of European descent but is much rarer in other groups. One out of 25 whites (4%) is a carrier. The normal allele for this gene codes for a membrane protein. If a person does not have this protein then the normal mucus that coats cells becomes thicker and stickier than normal. The mucus builds up in the pancreas, lungs, digestive tract and other organs, a condition that favors bacterial infections. Untreated, most children with cystic fibrosis die before their fifth birthday. Gentle pounding on the chest to clear mucus from clogged airways, daily doses of
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This note was uploaded on 03/25/2010 for the course GENETICS 329 taught by Professor Drt during the Spring '10 term at A.T. Still University.

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Pedigree Analysis Worksheet 06 - Pedigree Analysis Pedigree...

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