310CNSdepressantsnotes - CNS DEPRESSIANTS GENERAL CNS...

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CNS DEPRESSIANTS GENERAL CNS DEPRESSANTS AND ALCOHOL Lara Collier, Ph.D. Room 4117 Rennebohm Hall email: lcollier@wisc.edu This lecture will familiarize you with the common properties of the general CNS depressants. We will spend a large percentage of our time discussing alcohol, adverse effects of alcohol consumption, as well as treatment for alcohol dependence. We will also discuss barbiturates, inhalants and a couple of other general CNS depressants. RECOMMENDED READING: Julien et al., A Primer of Drug Action 11 th Edition Introduction to Part 2 (pages 93, 94) Chapter 4 “Ethyl Alcohol and the Inhalants of Abuse” Note: In terms of Pharmacodynamics, we will ONLY be discussing actions at glutamate and GABA receptors. In terms of the specific pharmacologic agents used to treat alcoholism, we will ONLY be discussing alcohol-sensitizing drugs. Chapter 5 Barbiturates, general anesthetics, etc… Note: We will NOT be discussing the sections that specifically talk about general anesthetics and antiepileptic drugs. Drugs you should know (on the exam both general and trade names will be provided): ethanol/ethyl alcohol disulfiram (Antabuse) calcium carbimide (Temposil) barbiturates (but not specific ones per se ) Methaqualone (Quaalude) Chloral hydrate (Noctec) Nitrous Oxide Gamma hydroxybutyrate (GHB) (Xyrem) Lecture notes: You do NOT need to memorize specific structures. Unless explicitly stated, you should be familiar with everything provided below. In the lecture notes below, the title of each slide is in italics . Some questions you should be able to answer based on the lecture are underlined , and space is provided to take notes. Slide: Lecture Outline 1) General properties of CNS Depressants A. Drugs that are CNS Depressants B. General effects of CNS Depressants C. Dose related physical and behavioral effects D. Pharmacodynamics E. Features of abused general CNS depressants F. Adverse reactions
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2) Alcohol A. Ethyl alcohol (Ethanol) B. Use: throughout the world C. Use: United States D. Pharmacokinetics i. Absorption ii. Distribution iii. Metabolism E. Nutrition F. BAC definition G. Definition of one "drink" H. BAC calculation I. Pharmacological effects 3) Chronic alcohol exposure A. Tolerance B. Withdrawal symptoms C. Alcoholism i. Definition ii. Adverse effects iii. Etiology (including other alcohol-related problems) iv. Treatment v. Alcohol sensitizing drugs 4) Barbiturates A. Issues/uses B. Pharmacokinetics: Solubility C. Pharmacodynamics D. Pharmacologic effects E. Physiological effects F. Adverse effects 5) Non-barbiturate sedative-hypnotics A. General info B. Examples i. Methaqualone ii. Chloral hydrate iii. GHB iv. Inhalants Slide: CNS DEPRESSANTS AND ALCOHOL Included in this group are (you are only responsible for the specific ones we discuss in the lecture): alcohol (ethanol/ethyl alcohol) barbiturates non-barbiturate sedative/hypnotics benzodiazepines (e.g. Diazepam (Valium)) gamma hydroxybutyrate (GHB) gamma butyrolactone (GBL)
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This note was uploaded on 03/25/2010 for the course PHARM 310 taught by Professor Marker during the Spring '10 term at Wisconsin.

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310CNSdepressantsnotes - CNS DEPRESSIANTS GENERAL CNS...

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