lecture5_slides - Pharm Sci 310 Feb 3rd 2009 Lecture 5 How...

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1 Lecture 5: How do brain cells communicate? Arash Bashirullah, PhD 5123 Rennebohm Hall contact: [email protected] Pharm Sci 310 Feb 3 rd , 2009 (reading: chapter 3 from textbook) summary of previous lecture… how do drugs work? – what is a receptor? – ligands and their properties – types of receptors describing the effects of drugs (drug binding kinetics) – drug response curves – drug safety and effectiveness nucleus CELL RECEPTORS receptor-ligand interactions: molecular switch OFF LIGANDS ON
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2 nucleus CELL RECEPTORS receptor-ligand interactions: reversible binding LIGANDS nucleus CELL receptor-ligand interactions: modulated signal intensity signal proportional to receptors bound nucleus CELL receptor-ligand interactions: modulated signal intensity signal proportional to time bound “tight” binding “loose” binding
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3 receptor-ligand interactions: specifcity oF binding strength of binding (“afFnity”) is structural summary of previous lecture… how do drugs work? – what is a receptor? – ligands and their properties – types of receptors describing the effects of drugs (drug binding kinetics) – drug response curves – drug safety and effectiveness lecture outline… overall anatomy of the brain – parts of the brain – the neuron – the synapse regulation of synaptic transmission
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4 the central nervous system (CNS) brain
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This note was uploaded on 03/25/2010 for the course PHARM 310 taught by Professor Marker during the Spring '10 term at University of Wisconsin.

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lecture5_slides - Pharm Sci 310 Feb 3rd 2009 Lecture 5 How...

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