lecture_#3_notes

lecture_#3_notes - Lecture #3 Outline Pharmaceutical...

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Lecture #3 Outline Pharmaceutical Sciences 310 Introduction to Pharmacology: Drugs and Their Actions Lecture #3: Pharmacokinetics lecturer: Paul Marker Assigned Reading: Chapter 1, A Primer of Drug Action The goal of this lecture is to explain the basic concepts in the field of pharmacokinetics, a sub-discipline of pharmacology. Basic terminology will be introduced, and specific examples will be used to illustrate the types of issues that pharmacokinetics investigates. Pharmacokinetics is the branch of pharmacology that examines the distribution and fate of drugs administered to the body. It asks the question: what does your body do to drugs? Important factors are drug Absorption, Distribution, Metabolism, and Excretion. I. Absorption is the movement of drugs into the bloodstream. a. The absorption of drugs is heavily influenced by the Route of Administration (the method used to deliver drugs into the body). b. The vascular system is important for understanding how drugs are handled by the body because it moves drugs to sites of action, sites of metabolism, and sites of secretion. The vascular system is also the location in the body where drug can most easily be measured in the clinic because obtaining a blood sample is a simple and straightforward medical procedure. (1) The heart is a pump that moves blood through the body. The movement of blood is called circulation. (2) Arteries are large vessels that blood travels in after it leaves the heart. Arteries lead to capillaries. (3) Capillaries are very small vessels in all tissues where nutrients, waste products, and drugs are exchanged between blood and the cells of the body. The group of capillaries in a tissue is often referred to as a capillary bed . (4) Veins are the larger vessels that follow capillaries and return blood to the heart. (5) Portal systems are groups of vessels arranged such that blood flows through a second capillary bed before reaching the heart. This is an important concept for oral drug delivery because of a portal system between the gastrointestinal tract and the liver.
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c. The Area Under the Curve (AUC) is a way to gauge a drug’s bioavailability in the body. (1) The AUC is the geometric area under a curve that plots the venous drug concentration on the Y-axis and time on the X-axis. (2) AUC is directly proportional to bioavailability and inversely proportional to
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lecture_#3_notes - Lecture #3 Outline Pharmaceutical...

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