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310alzheimersnotes10 - Pharmaceutical Sciences 310...

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Pharmaceutical Sciences 310 Introduction to Pharmacology: Drugs and Their Actions Lecture Notes: Alzheimer’s Disease: Basis and Treatment lecturer: Lara Collier The goal of this lecture is to familiarize students with dementia, specifically Alzheimer’s disease (AD). Basic characteristics and causes of dementia will be introduced, but the majority of the lecture will focus on the symptoms, diagnosis, cause and treatment of AD. The results of several recent clinical trials as well as potential avenues for AD treatment will be covered. RECOMMENDED READING: A Primer of Drug Action review the part of chapter 3 that deals with acetylcholine (pages 74-78) Alzheimer's disease in chapter 11 (pages 405-413) Although the text covers the topic of drugs used to treat mood alteration and behavioral changes in AD, we will not cover them in class and you will not be tested on them. This webpage provides a good introduction to the disease: http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp DRUGS YOU SHOULD BE FAMILIAR WITH AND THEIR ACTIONS: Approved treatments for AD: Donepezil [ doe NEP e zil] (Aricept) Rivastigmine [ri va STIG meen ] (Exelon) Galantamine [ga LAN ta meen] (Razadyne) Tacrine [tak-reen] (Cognex) (use rare) Memantine [ meh MAN teen ] (Namenda) Investigational agents for AD: LY450139 Dihydrate PBT2 Bapineuzumab (bap ee nue zoo mab) Resveratrol Other drugs/supplements we will talk about: Ibuprofen (Advil, others) (Alzhemed®) homotaurine/tramiprosate AKA "Vivimind" Vitamin E Vitamin B Ginkgo biloba Hints: Note that “mab” at the end of a drug indicates it is an antibody, you will see this in the cancer lecture as well. You do NOT need to memorize chemical structures. Lecture notes: In the lecture notes below, the title of each slide is in *** italics*** . Some questions you should be able to answer based on the lecture are underlined , and space is provided to take notes.
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***Slide: LECTURE OUTLINE*** - Definition of dementia - Alzheimer’s characteristics - Alzheimer’s biochemistry - Current treatments - Stumbling blocks/future opportunities ***Two Slides: Dementia*** What is dementia? People with dementia can have difficulty planning simple tasks, language recall and performing complex mental tasks. The can become disoriented and misplace things. They can also have personality changes like becoming anxious, agitated, moody, apathetic or displaying poor judgment. They become increasing reliant on others to take care of them. Dementia is not a single disease: What is reversible dementia and what are some example causes? What is irreversible dementia and what are some example causes? Dementia prevalence: 1 in 20 people over the age of 65 (prior to 65 is called pre-senile or early-onset) 1 in 5 over the age of 80 By 2050, it is predicted over 100 million people worldwide will suffer from dementia (although this last fact is interesting you won't be quizzed on it).
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