310antipsychoticnotes10 - Pharmacology 310: Introduction to...

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Unformatted text preview: Pharmacology 310: Introduction to psychosis and antipsychotics 2/23/2010 and 2/25/2010 lecturer: Lara Collier The goals of this lecture are to familiarize you with the basic diagnostic criteria for schizophrenia, the possible causes of the disease and the defects in neurotransmission that are thought to cause symptoms. We will discuss the pharmacodynamics, uses, limitations and side effects of antipsychotic drugs. We will conclude with a brief discussion of recently FDA approved antipsychotics and future directions for the pharmacotherapy of schizophrenia. Reading for these lectures: A Primer of Drug Action Chapter 3- review the part on Dopamine Pathways (pages 81-82 in the 11th edition) Chapter 9- antipsychotic drugs DRUGS we will discuss ( Trade names in parentheses. On the exam, both will be provided, e.g. Chlorpromazine/(Thorazine)): First Generation Antipsychotics(FGA)/Conventional Agents Phenothiazines f -n - th - - z ns e.g., Chlorpromazine (Thorazine) klor proe' ma zeen Butyrophenones by-t -r -f - n n e.g., Haloperidol (Haldol) hal oh per i dole Second Generation (SGA) /Atypical Agents Clozapine (Clozaril) kloe' za peen Olanzapine (Zyprexa) oh lan ze peen Quetiapine (Seroquel) kwe tye a peen Risperidone (Risperdal) ri sper i dohn Ziprasidone (Geodon) zi pray' si dohn Aripiprazole (Abilify) ay ri pipray zole Asenapine (Saphris) ay sen a peen Iloperidone (Fanapt) ilo-PER-i-done Lecture notes: In the lecture notes below, the title of each slide is in italics . Some questions you should be able to answer based on the lecture are underlined , and space is provided to take notes. Slide: Outline of Antipsychotic lectures A. Introduction 1. Nature of psychosis and schizophrenia 2. Diagnostic criteria 3. Incidence 4. Schizophrenia etiology B. Possible Neurotransmitter Defects in Schizophrenia 1. Dopamine hypothesis 2. Serotonin hypothesis 3. Glutamate dysfunction theory C. Pharmacology of Antipsychotic Agents 1. First generation/conventional 2. Second generation/atypical 3. Adverse reactions D. Clinical use 1. Indications 2. Drug choice E. Where to go from here? 1. Recent FDA approvals 2. Possible future directions Slide: NATURE OF PSYCHOSIS AND SCHIZOPHRENIA Psychosis denotes a variety of mental disorders characterized by a loss of contact with reality and impairment great enough to prevent the individual from participating in everyday life. Schizophrenia is a particular group of psychoses characterized by clear sensorium but marked thinking disturbance. The disease influences perception, thought content, thought process, affect and daily functioning. What is a common misperception about schizophrenia?...
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This note was uploaded on 03/25/2010 for the course PHARM 310 taught by Professor Marker during the Spring '10 term at Wisconsin.

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310antipsychoticnotes10 - Pharmacology 310: Introduction to...

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