310antipsychotics10toprint - DRUGS AND THEIR ACTIONS...

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1 DRUGS AND THEIR ACTIONS SCHIZOPHRENIA AND ANTIPSYCHOTIC DRUGS Lara Collier SCHIZOPHRENIA AND ANTIPSYCHOTICS A. Introduction 1. Nature of psychosis and schizophrenia 2. Diagnostic criteria 3. Incidence 4. Schizophrenia etiology B. Possible Neurotransmitter Defects in Schizophrenia Dopamine hypothesis 2. Serotonin hypothesis 3. Glutamate dysfunction theory C. Pharmacology of Antipsychotic Agents First generation/conventional Second generation/atypical Adverse reactions D. Clinical use Indications 2. Drug choice E. Where to go from here? 1. Recent FDA approvals 2. Possible future directions NATURE OF PSYCHOSIS AND SCHIZOPHRENIA Psychosis denotes a variety of mental disorders characterized by a loss of contact with reality and impairment great enough to prevent the individual from participating in everyday life. Schizophrenia is a particular group of psychoses characterized by clear sensorium but marked thinking disturbance. The disease influences perception, thought content, thought process, affect and daily functioning. It is NOT multiple/split personalities (a common misconception!).
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2 SCHIZOPHRENIA SYMPTOM DEFINITIONS Impaired attention Impaired working memory Impaired executive function Affective flattening Alogia Anhedonia Avolition Disorganized thought Disorganized behavior Delusions (unusual thought content) Hallucinations Cognitive Negative Positive Schizophrenia Symptom Clusters -Positive reflect an excess or distortion of normal function -Negative reflect a decrease or loss of normal function Example: Alogia -Cognitive - defects in memory and attention Example of alogia Alogia Normal speech Q: Do you have any children? A: Yes. Q: How old are they? A: Six and sixteen. Q: Are they boys or girls? A: One is a boy, the other is a girl. Q: Who is the sixteen year old? A: The boy. Q: What is his name? A: Edmo nd. Q: And the girl's? A: Alice. Q: Do you have any children? A: Yes, a boy and a girl. Q: How old are they? A: Edmond is sixteen and Alice is 6. SCHIZOPHRENIA: DIAGNOSTIC CRITERIA If a history of a pervasive developmental disorder is present, there must be symptoms of hallucinations or delusions present for at least 1 month. F. Disorder is not due to a medical disorder or substance use. E. Schizoaffective or mood disorder has been excluded. D. Duration: Continuous signs of the disorder for at least 6 months. This must include at least 1 month of symptoms fulfilling criterion A (unless successfully treated). This 6 months may include prodromal or residual symptoms. C. Social/occupational dysfunction: For a significant portion of the time since onset of the disorder, one or more major areas of functioning such as work, interpersonal relations, or self-care are significantly below the level prior to onset. B. Characteristic symptoms: Two or more of the following, each persisting for a significant portion of at least a 1-month period: (1) delusions (2) hallucinations (3) disorganized speech (4) grossly disorganized or catatonic behavior (5) negative symptoms
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This note was uploaded on 03/25/2010 for the course PHARM 310 taught by Professor Marker during the Spring '10 term at Wisconsin.

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310antipsychotics10toprint - DRUGS AND THEIR ACTIONS...

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