2010_antidepressants(pp) - ANTIDEPRESSANTS March 2 and 4...

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2/26/10 1 ANTIDEPRESSANTS March 2 and 4, 2010 Paul Marker, Ph.D. Depression Major Depressive Disorder (MDD) and related conditions Is a chronic, recurring and potentially life-threatening illness Is the fourth most disabling disease worldwide Depression worsens the health of people with other chronic diseases and is associated with increasing disability over time Depression Incidence 10% of men and 25% of women experience depression in their lives Depression is responsible for 70% of psychiatric hospitalizations Depression is responsible for 40% of suicides Only about 21% of cases yearly are adequately treated
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2/26/10 2 Depression is an affective disorder Characterized by alterations in emotion and mood Diagnosis bases on presence of at least 5 symptoms daily (or almost every day) for at least two weeks Symptoms involve energy, sleep, mood, self-concept, weight, thoughts of suicide Anxiety is also seen in many patients with depression (Antidepressant drugs are indicated for anxiety)
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2/26/10 3 Types of Depression: Major Depressive Disorder (MDD) also called Major Depression MDD is characterized by a combination of symptoms that interfere with a person's ability to work, sleep, study, eat, and enjoy once–pleasurable activities. MDD is disabling and prevents a person from functioning normally An MDD episode may occur only once in a person's lifetime Often MDD recurs throughout a person's life Types of Depression: Dysthymic Disorder also called dysthymia dysthymia is characterized by long–term (two years or longer) but less severe symptoms compared to MDD Symptoms may not disable a person but can prevent one from functioning normally or feeling well People with dysthymia may also experience one or more episodes of major depression during their lifetimes Types of Depression: Psychotic depression Occurs when a severe depressive illness is accompanied by some form of psychosis May involve a break with reality May involve hallucinations May involve delusions.
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2/26/10 4 Types of Depression: Postpartum depression Is diagnosed if a new mother develops a major depressive episode within one month after delivery It is estimated that 10 to 15 percent of women experience postpartum depression after giving birth Types of Depression: Seasonal affective disorder (SAD) Is characterized by the onset of a depressive illness during the winter months Is related to the relative lack of natural sunlight The depression generally lifts during spring and summer SAD may be effectively treated with light therapy, but nearly half of those with SAD do not respond to light therapy alone Antidepressant medication and psychotherapy can reduce SAD symptoms, either alone or in combination with light therapy Types of Depression: Bipolar disorder Also called manic-depressive illnessis Is not as common as major depression or dysthymia Is characterized by cycling mood changes-from extreme highs (e.g., mania) to extreme lows (e.g., depression)
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  • Spring '10
  • Marker
  • Selective serotonin reuptake inhibitor, Major depressive disorder, Antidepressant, monoamine oxidase inhibitors

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