2-11 - The role of CD36 (Scavenger receptor B) in...

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Unformatted text preview: The role of CD36 (Scavenger receptor B) in atherosclerosis development. Red stains for lipids in foam cells ApoE-/- CD36-/- ApoE-/- CD36 +/+ ApoE-/- CD36-/- ApoE-/- CD36 +/+ CD36-/- macrophage show reduced binding and uptake of oxidized LDL. Barrier Bacteria complements lysis C3-opsonized M Mast cells Infammatory mediators M neutrophil monocytes phagocytosis blood infammation Tissue injury Primary immune response Activation oF B and T cells Barrier Bacteria complements lysis C3-opsonized IgG-opsonized M Mast cells Infammatory mediators M neutrophil monocytes phagocytosis blood infammation Tissue injury Secondary immune response IgA IgG Activation oF B and T cells Antibodies Heavy chain (H) Light chain (L) V H C H1 C H1 V H C H2 C H3 C H2 C H3 V L V L C L C L Each chain is composed of immunoglobulin (Ig) domains. Variable region Constant region 2 isotypes of C L : and 5 isotypes of C H : , , , , V H C H1 C H1 V H C H2 C H3 C H2 C H3 V L V L C L C L Antigen binding site Effector functions Papain V H C H1 V L C L C H1 V H V L C L C H2 C H3 C H2 C H3 Fab Fc Variable region binds antigen through complementarity determining regions (CDRs). L1, L2, L3 (CDR1, CDR2, CDR3) H1, H2, H3 (CDR1, CDR2, CDR3) Framework region (FR) epitope CDRs are the most variable parts of antibodies N C CDRs epitope Antibody AfFnity AfFnity: the strength of association between a single epitope of antigen and a single antigen binding site of antibody. V H C H 1 C H 1 V H C H 2 C H 3 C H 2 C H 3 V L V L C L C L a b The combination of V H and V L forms a single antigen binding site Single epitope Single antigen binding site K a = [Ag-Ab] [Ag][Ab] K d = [Ag][Ab] [Ag-Ab] Ag + Ab Ag-Ab AfFnity is expressed by association constant (K a ) or dissociation constant (K d ). Valency The number of antigen binding site of a single antibody molecule.The number of antigen binding site of a single antibody molecule....
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2-11 - The role of CD36 (Scavenger receptor B) in...

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