3-9 - Self-reactive B cells can be rescued by receptor...

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Self-reactive B cells can be rescued by receptor editing at the IgL locus. Ig κ Transient re-expression of Rag-1 and Rag-2 12 bp-RSS 23 bp-RSS New V κ region IgH cannot undergo receptor editing.
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Immature B cells exit bone marrow and migrate to spleen to complete maturation. sIgM + Immature B cells spleen Immature B cells (transitional B cells) Mature B cells sIgM + sIgM + IgD + Blood circulation
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Mature B cells express both IgM and IgD on cell surface. VDJ IgH locus C μ C δ μ mRNA sIgM sIgM Immature B cells Alternative splicing μ mRNA δ mRNA sIgM sIgD Mature B cells
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Old red blood cells are destroyed in red pulp. WP White pulp is lymphoid tissue.
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Follicular dendritic cells (FDC) B cell follicle Follicular B cells Marginal sinus B cells enter into B cell follicles through marginal sinus. From central arteriole CCL21 CXCL13 CCR7 CXCR5 B cells are attracted to B cell follicles by chemokines. BAFF helps the survival of follicular B cells FDC
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Mature B cells circulate between blood and secondary lymphoid organs. spleen Lymph node B cells exit blood circulation, enter into B cell follicles, and exit through efferent lymph. Spleen B cells enter into B cell follicles, and exit through blood circulation. Peyer’s patch Mucosal tissues B cells exit blood circulation, enter into B cell follicles, and exit through efferent lymph. Lymphatic circulation merges with blood circulation Efferent lymph Efferent lymph Afferent lymph Tissue fluids enter afferent lymph Mature B cells have a half-life of 4.5 months.
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Lymph is returned to the blood through subclavian vein.
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B cells in blood circulation
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This note was uploaded on 03/25/2010 for the course BIO 360K taught by Professor Bryant during the Spring '09 term at University of Texas at Austin.

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3-9 - Self-reactive B cells can be rescued by receptor...

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