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Unformatted text preview: 1 02/13/07 BILD1 - Lecture 10 1 BILD1 The Cell Prof. Lisa M. Boulanger 02/13/07 BILD1 - Lecture 10 2 Problem Set 4 posted,discussed this week Todays lecture: 3 movie links Regrade requests must be submitted in writing, on paper by THIS THURSDAY Whole exam will be regraded Simple addition errors will just be corrected exam will not be regraded 02/13/07 BILD1 - Lecture 10 3 Cell signaling: local and long distance Local signaling Gap junctions, plasmodesmata (membrane contact) Cell-cell recognition (cell surface molecule contact) Autocrine signaling (to self) Paracrine signaling (to neighbor) Long-distance signaling Hormones Highlights from previous lecture: 02/13/07 BILD1 - Lecture 10 4 Highlights from previous lecture: Three stages of signaling: Reception (conformational changes) G protein coupled receptors Tyrosine kinase receptors Ion channels Intracellular receptors Transduction Phosphorylation Second messengers cAMP G proteins IP 3 , DAG, Ca 2+ Response Transcription factors Specificity, amplification, reversal 02/13/07 BILD1 - Lecture 10 5 THIS LECTURE: MITOSIS 02/13/07 BILD1 - Lecture 10 6 The continuity of life Is based upon the reproduction of cells, or cell division 2 02/13/07 BILD1 - Lecture 10 7 Unicellular organisms Reproduce by cell division 100 m Reproduction 02/13/07 BILD1 - Lecture 10 8 Multicellular organisms depend on cell division for Development from a fertilized cell Growth Repair 20 m 200 m Growth Tissue renewal and repair 8 cell embryo 02/13/07 BILD1 - Lecture 10 9 The cell division process Is an integral part of the cell cycle Cell division results in genetically identical daughter cells Cells duplicate their genetic material Before they divide, ensuring that each daughter cell receives an exact copy of the genetic material, DNA 02/13/07 BILD1 - Lecture 10 10 Cell Cycle Prokaryotes versus Eukaryotes Prokaryotic Eukaryotic Chromosomes 1 circular, + plasmids several, linear DNA 4.6 million base pairs (BP) 3 Billion BP Cell division time 20 minutes 24 hours Mechanism of division binary fission mitosis, cytokinesis 02/13/07 BILD1 - Lecture 10 11 Cellular Organization of the Genetic Material A cells endowment of DNA, its genetic information Is called its genome 02/13/07 BILD1 - Lecture 10 12 Some diploid numbers Homo sapiens (human) 46 Mus musculus (house mouse) 40 Drosophila melanogaster (fruit fly) 8 Caenorhabditis elegans (microscopic roundworm) 12 Saccharomyces cerevisiae (budding yeast) 32 Arabidopsis thaliana (plant in the mustard family) 10 Xenopus laevis (South African clawed frog) 36 Canis familiaris (domestic dog) 78 Gallus gallus (chicken) 78 Zea mays (corn or maize) 20 Muntiacus reevesi (the Chinese muntjac, a deer) 23 Muntiacus muntjac (its Indian cousin) 6 Parascaris equorum var. univalens (parasitic roundworm) 2 Cambarus clarkii (a crayfish)...
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This note was uploaded on 03/26/2010 for the course BENG 110 taught by Professor Schmid-schoenbein during the Spring '08 term at UCSD.
- Spring '08