exam_1-new-answers - Zoo/Psych/Neuro523 NOCALCULATORS...

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Zoo/Psych/Neuro 523 Exam 1-answers 2008 NO CALCULATORS!   Please write your answers to these 4 questions on 4 different sheets of paper.   Be sure to write your  name on each sheet. 1. (20 points) What is the hydrophobicity plot of a protein?  What are 2 features that you would expect to see  in a protein that is inserted into the membrane?    (3 sentences maximum!) The hydrophobicity plot of a protein is the result of a scan of the amino acid sequence,  summing the values of the hydrophobicities of each amino acid side chain in a moving window.  The plot identifies regions of the protein sequence in which there are groups of adjacent  hydrophobic amino acids.  A transmembrane protein has stretches of 20 - 25 hydrophobic  amino acids, which allow the polypeptide chain to be arranged in a membrane-spanning alpha  helix with the hydrophilic groups of the backbone hydrogen-bonded to each other, and allowing  the side chains to interact with the hydrophobic tails of the fatty acids of the membrane  phospholipids. 2.  (20 points – 5 points each part) a)  Please draw the molecular structure of lecithin (phosphatidyl choline) Show glycerol backbone with 2 fatty acids esterified onto 2 of the OH groups and a phosphate 
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  • Fall '08
  • Stretton
  • new plasma membrane, specific membrane resistance., specific membrane resistance, hydrophobic  amino acids

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exam_1-new-answers - Zoo/Psych/Neuro523 NOCALCULATORS...

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