PROBLEM_SET_1.466n - 4. What is the difference between...

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Genetics 466 Fall 2008 Sean Carroll PROBLEM SET #1 (lectures 14-16) You should be familiar with the following terms: Hydrogen bonds Okazaki fragment nucleoside origin of replication nucleotide phosphodiester bond DNA polymerase I Theta structures DNA polymerase II replication fork DNA ligase telomerase 1. In what component parts do RNA and DNA differ? How do their general structures differ? 2. A new organisms has been found and the base composition of its DNA was determined to be 22 percent cytosine. What is the percentage of thymine? guanine? adenine? The uracil content of RNA is found to be 24 percent. Explain. 3. What holds the DNA double helix together? What is an easy way to destroy the double helix structure?
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Unformatted text preview: 4. What is the difference between conservative and semi-conservative replication? 5. Why does replication proceed from the 5 to 3 direction? 6. The rate of DNA replication averages 1000 nucleotides per second. How long does it take E. coli to replicate its 4,000 kb genome if replication is bidirectional from one origin? Unidirectional from one origin? How long would it take to replicate a human chromosome of 150,000 kb if replication is bidirectional from one origin at the centromere and the rate is 3,000 nucleotides per minute? From 1,000 origins? 7. What is meant by discontinuous replication? 8. What are the three physical requirements for DNA polymerase to proceed? 9. What is a primer?...
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This note was uploaded on 03/26/2010 for the course GENETICS 466 taught by Professor Staff during the Fall '08 term at Wisconsin.

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