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44110aHW1Ans - BIOCHEMISTRY 441 Spring 2010 Instructor...

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BIOCHEMISTRY 441 Spring 2010 Instructor: David O. Peterson Homework 1 Answers 1. As we will learn later in the semester, glucose can be stored in several tissues as a polymer called glycogen. Glucose monomers are released from glycogen by the action of glycogen phosphorylase, which catalyzes the reaction shown below, where the subscript on the glycogen indicates the number of glucose monomers in the glycogen polymer. glycogen n + P i glucose-1-P + glycogen n-1 The glucose-1-P can then be converted to glucose-6-P by the action of phosphoglucomutase, which does not require ATP. How much ATP would you expect to be generated during glycolysis using the glucose-1-P derived from the breakdown of glycogen? Explain your answer. (Express your answer in moles of ATP generated per mole of glucose-1-P.) Glucose-6-P generated from glycogen bypasses the hexokinase step in glycolysis. Consequently, only one ATP needs to be invested to get to the "payoff" phase. Thus, there will be a net synthesis of 3 ATPs per glucose-1-P generated by this pathway.
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