L10 - Exam NEWS There were scantron problems Bad News...

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Exam NEWS: There were scantron problems. Bad News: Everyone’s score is 4 points lower due to misgrading by the scantron. The machine gave 3 pt credit for A) 3&5 and B) 23 &25 rather than the correct 1 point. Good News: A student successfully challenged the question A) 36 and B) 32 for being poorly worded so you all will get these 3 points.
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Exam NEWS: For extra credit, you got credit for correct answers but were not penalized for incorrect answers. Therefore, the important number is your percentage score which is know slightly changed due to the above corrections. I am having the reports reprinted so you can have a record of these changes. I will post the key as soon as the last make-up is taken Any issues with the exam need to be addressed in writing to me within 1 week of the turn-back
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Exam NEWS: Several students asked me for study advice so I asked several of the top scorers: 1) Top scorers either came to lecture or watched from home (keeping up—not letting 2 or 3 lectures pile up). One said not to take notes in class, just listen. 2) Top scorers reviewed the lectures AGAIN shortly after hearing them. They spent time on every slide, redrawing the diagrams and explaining them to a study/buddy. 3) Top scorers recommended going to sections (sometimes 2 sections/week) until all the concepts are crystal clear 4) Top scorers read the book on the figures I presented in lecture 5) Top scorers did the problem sets 6) Top scorers emphasized understanding the concepts and not just memorizing the information.
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Mutant receptor tyrosine kinases can be used to inhibit signaling P P P
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Intracellular signaling molecules bind to phosphorylated tyrosines on the activated receptor Basic principle Fig 15-21B. Assembly of a signaling complexes following receptor activation. Receptor auto- phosphorylates, creating binding sites for signaling proteins.
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Proteins can also have SH3 domains which mediate protein-protein interactions by recognizing a proline- rich motif Basically there are a plethora of binding domains that recognize specific motifs I would like you to know these
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The Ras protein is a GTPase that relays the signal received by receptor tyrosine kinases Tyrosine kinases activate Ras indirectly through GEF often through adaptor protein called Grb2. Alberts 5th edition give example of photoreceptor in fly eye
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The GTP-bound form of Ras activates a MAP (mitogen activated) kinase cascade Short lived signaling events are converted to longer lasting signals by activating the MAP kinase cascade This cascade requires phosphorylation on both a tyrosine and threonine residue for full activation. This occurs by MAP-kinase kinase
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Scaffold proteins confer specificity on MAP kinase cascades Basic Principle Fig 15-21A: Scaffold proteins organize signaling proteins; here: different MAP kinase pathways in yeast.
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