PracticeExam3 - Professor Lindsay Hinck Bio 110 Fall 2008...

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Professor Lindsay Hinck Bio 110 Fall, 2008 Midterm III Version A Remember to manage your time wisely. You have 35 problems: 5 True/False and 30 multiple choice. This means approximately 5 minutes/ question so you have to move along. Remember to write and bubble in your 1) Name 2) Test Version (A or B) 3) Student ID on the scantron sheet.
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2 QUESTIONS 1-5) True/False Questions: Mark A for True or B for False (2 points each, total 10 points) 1) To avoid the congestion that would occur if 2-way traffic through a single nuclear pore was allowed, nuclear pore complexes are specialized so that some mediate import and others mediate export. 2) Once formed, kinetochore microtubules depolymerize at their plus ends throughout mitosis. 3) Virtually all epithelia are anchored to other tissues on their basal side and free of such attachment on their apical side. 4) There are different membrane bound neighborhoods inside the nucleolus that are responsible for gene silencing and expression. 5) Histone variants can be inserted into nucleosomes without unwrapping the DNA. 6) Mouse L-cells have proven to be a very useful model system for investigating the properties of cadherins because they do not normally express any cadherin. You decide to explore cadherin interactions by mixing together L-cells that express E-cadherin and high levels of P- cadherin with L-cells expressing N-cadherin and low levels of P-cadherin. What sort of final architecture do you expect of the cell balls that will aggregate? Below are 5 possibilities. Based on what you learned in class and by doing the problem set, select one of the aggregated balls below.
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3 QUESTIONS 7 & 8) You are trying to figure out the function of a motor protein, called V-8, in spindle assembly. You do this by removing V-8 from frog egg extracts by immunodepletion. Below is the data for your experiment with wild-type V-8 present (left) and with it absent (right). 7) Based on these data, please tell me on which microtubules V-8 is located. A) astral microtubules B) kinetochore microtubules C) interpolar (aka overlap) microtubules 8) Based on these data, please tell me the type of motor V-8 is. A) Plus-end directed motor protein B) Double-headed, plus-end directed motor protein C) Minus-end directed motor protein D) Cannot tell from this experiment. QUESTIONS 9 & 10) The activities of Wee1 tyrosine kinase and Cdc25 tyrosine phosphatase determine the state of phosphorylation of tyrosine 15 in the Cdk1 component of M-Cdk. When tyrosine 15 in the Cdk1 component is phosphorylated, M-Cdk is inactive; when tyrosine 15 is not phosphorylated, M-Cdk is active. Just as the activity of M-Cdk itself is controlled by phosphorylation, so too are the activities of Wee1 kinase and Cdc25 phosphatase. The regulation of these activities can be studied in extracts of fission yeast cells. In such extracts, Wee1 tyrosine kinase is ACTIVE and Cdc25 tyrosine phosphatase is INACTIVE.
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