PS9KEY - Professor Hinck Bio 110, Fall, problem set 10 1)...

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Professor Hinck Bio 110, Fall, problem set 10 1) Describe the 3 main classes of spindle microtubule in animal cells and their functions during mitosis. ANS: Astral, kinetochore, and interpolar microtubules all radiate from the spindle poles, with their plus ends directed outwards. Astral microtubules, which radiate in all directions, act as ‘handles’ for orienting and positioning the spindle in the cell. In addition, those in contact with the cell cortex aid in separation of the spindle poles during anaphase. Kinetochore microtubules link chromosomes to the spindle and are responsible for movement of the sister chromatids to the poles. Interpolar microtubules interdigitate at the equator of the spindle and are responsible for the symmetrical, bipolar shape of the spindle. Their movement relative to one another pushes the poles apart at anaphase. 2) The balance between plus-end directed and minus-end directed motors determines spindle length. Where in the spindle are these motors located and how to they operate to control spindle length? ANS: The two types of motors operate on the interpolar microtubules. Plus- end directed motors (example kinesin 5,4, 10) tend to push the spindle poles apart by decreasing the overlap, whereas minus-end-directed motors (example
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This note was uploaded on 03/28/2010 for the course MCD BIO 110 taught by Professor Hinck during the Fall '09 term at UCSC.

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PS9KEY - Professor Hinck Bio 110, Fall, problem set 10 1)...

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