Lecture 6 Cell and molecular endo w10

Lecture 6 Cell and molecular endo w10 - Lecture 6 Cell and...

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Lecture 6 Cell and Molecular Endocrinology Part II: Membrane receptor signaling I. General properties of membrane receptor signaling II. G protein coupled receptors cAMP as a second messenger a. b. DAG/IP3/Ca2++ as second messengers I. eceptor tyrosine kinase signaling III. Receptor tyrosine kinase signaling Conservation of insulin signaling IV. Growth hormone/prolactin receptor signaling
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I. Membrane Receptors for Hydrophilic Hormones Can act faster than nuclear receptors (minutes) Activate 2 nd messenger cascades Gets signal across membrane Amplifies hormonal signal Cross-regulation with other signals Can change cell function without new protein synthesis Cell shape, movement, ion channel activity, cretion enzyme activity secretion, enzyme activity Can also change cell function via new protein synthesis
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II. G-protein coupled receptors (over 1,000 in vertebrate genome) Bockaert and Pin, 1999
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A. G protein coupled receptors: cAMP as second messenger e.g. Epinephrine, glucagon, TSH, H H LH, FSH, ACTH, ADH (kidney-
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Lecture 6 Cell and molecular endo w10 - Lecture 6 Cell and...

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