Micro 251

Micro 251 - T he Acquired Immune System w here innate...

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The Acquired Immune System – where innate immune response works as quickly as possible, the acquired immune response takes about 3 days to get going, 2 weeks to make antibodies – takes a longer time for the cells to adapt to the situation at hand (infection) – both response systems get activated at same time, it just takes the acquired system longer. I am going to go through this chapter in a slightly different order than it is presented in the text. Please be patient, I think it makes more sense my way. I will indicate the figures (as always) in the outline. Lymphocytes – White blood cells (leukocytes) that have antigen-specific receptors on their surface 1. Characteristics A. Inducibility- must be activated to respond – so there are toll-like receptors that help activate the response B. Specificity- only the pathogen /antigen that activates it will be recognized. C. Memory (p. 367) 1) Once that pathogen has been seen and responded to, the immune system will “remember” it. Such as response to the chicken pox after being infected the first time – not that your body repels the virus, just that the immune system recognizes it so understands how to respond after first time. a. Primary response – first time the immune system “sees” an antigen /pathogen - then a Secondary or memory response – grows every time you are infected with organism after primary response – grows more and more antibodies to fight off each time . b. Different from a primary infection – first disease – that may have destroyed innate immune system first time around??, and then a secondary infection, one that results as complication of the primary infection 2) Allows us to respond better, faster, more specifically than we did the first time we encountered a specific pathogen. 1
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D. Humoral versus Cellular Immunity 1) B cells and antibodies -B cells are said to be part of a humoral response, because they produce products (antibodies) that are the actual mediators that destroy pathogens. These antibodies are found in the blood and body fluids that used to be known as the body’s humors- hence the term humoral response. 2) T cells-T cells are said to be part of a cell mediated response, because they interact directly with cells to function. They come in a couple of effector forms: inflammatory, helper, cytotoxic and regulatory. 2. Lymphoid system. A. Blood and circulation-closed system pumped by a heart. B. Lymph-how does lymph flow through the body?. – is between the cells of your body – movement of muscles moves fluid. 1)
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This note was uploaded on 03/28/2010 for the course MCRO 251 taught by Professor Lorrainecramer during the Fall '09 term at UNC.

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Micro 251 - T he Acquired Immune System w here innate...

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