Alimentary Outline-Fall 2009

Alimentary Outline-Fall 2009 -...

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Bacterial Diseases of the Alimentary System   Fecal/Oral -route of transmission is ingestion and shedding of organisms in feces. Kauffmann-White system- series of antibodies that differentiate serovars based on organism’s capsule (K), cell  wall (O) and flagella (H). Gastroenteritis- Diseases causing inflammation of the stomach and intestinal mucosa causing vomiting and  diarrhea. Dysentery- Severe diarrhea accompanied by blood and mucous. Enterotoxin- an exotoxin that targets intestinal tract. I. Alimentary system 1. Overview of the Alimentary system (Fig. 25.1) A. Diarrhea and vomiting are defense mechanisms, which may also harm when they occur in  excess or extremes. (Loss of fluids, nutrients) B. Intoxications versus Infections  C. Intoxication occurs from ingestion of preformed toxins secreted by organisms. NO actual  infection by bacteria occurs. D. Infection is when an organism enters the GI tract and multiplies.  E. May or may not then produce an exotoxin.  II. Bacterial Diseases of the upper Alimentary system. 1. Gastritis  (Table 25.2) Helicobacter pylori, short spiral gram negative with polar flagella (Fig.  25.7)  Causes stomach ulcers – organism only lives in humans. A. Organisms highly specialized for life in the stomach. 1
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Urease neutralizes acid in stomach. C. Special flagella allow them to penetrate mucous layer of stomach (Fig. 25.8) – keeps it from being destroyed from acid of stomach D. Destruction of stomach epithelium due to inflammatory response to infection. Having this does not give one gastric cancer – however large ratio in people with gastric cancer (Maybe – didn’t hear all she said) 1) Injects proteins into cells which leads to change in shape and surface characteristics. 2) Localized abdominal pain can lead to bleeding with ulcers and cancer. E. Fecal/oral transmission. F. Increasing incidence of carriage with age. 2. Mumps (Table 25.4) A. Mumps virus, single antigenic type, RNA virus. B. Incubation period is 16-18 days. Inflammation and swelling of the parotid glands, fever. C. Symptoms in individuals past puberty more severe. Target organs change as individual mature. – Infectious before and after we see symptoms 1) Orchitis – a rapid, intensely painful swelling of one or both testicles to three to four times their normal size . 2) Inflammation of the ovaries or testicles – T cytotoxic cells will migrate to testicles to kill virus but also kills sperm – pretty rare though . D. Transmission
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This note was uploaded on 03/28/2010 for the course MCRO 251 taught by Professor Lorrainecramer during the Fall '09 term at UNC.

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Alimentary Outline-Fall 2009 -...

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