blood and lymphatics -Fall 2009

blood and lymphatics -Fall 2009 - /wounds 1 A...

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Infections of the blood and lymphatics/wounds. 1. Gram negative septicemia  A. Septic shock is most common with infections by gram-negative organisms, staphylococci, or  meningococci.   B. Toll-like receptors cause the release of a large number of mediators, including tumor necrosis factor  (TNF), leukotrienes, histamine, and IL-1 (Fig. 28.3) C. Endotoxin activates clotting factors, and causes DIC. Leaky blood vessels  (increased capillary leakage)  mean that the patient will not respond to fluid replacement therapy.  Endotoxin effect on macrophages  in lungs can cause irreversible lung damage, even if infection is cleared. D. Early administration with antibiotics are life-saving. Antibiotics should be continued for several days  after shock resolves and the primary focus of infection is eradicated. Problem leads from death of  bacteria as well. E. 500,000 cases/yr in US, 40-60% mortality. 1. Epstein-Barr Virus  (EBV)  DNA virus,   herpesvirus family (Table 28.6) A. Infectious mononucleosis  – Do not confuse this with “walking pneumonia” 1) Virus infects oral epithelium then travels to lymph nodes where it  infects B cells (Fig. 28.8). a. May be productive infection-produces virons. b. May be non-productive latent infection.  The virus becomes latent in your B cells. Only  replicates in B cells. T cells begin to kill the abnormal B cells c. Causes production of  heterophile antibodies.  Calls for the production of a bunch of wacky  antibodies 2) Symptoms  – The virus first infects the URT and then disseminates to salivary glands a. Disease in third world countries vs. developed countries. b. Long incubation period- 30 to 60 days. c. Symptoms in early age are mild. If disease is acquired in young adulthood, more  symptomatic. d. Fever, sore throat, swollen lymph nodes in the neck, enlarged spleen and general  weakness/exhaustion.  3) Transmission is via saliva of infected individuals-“Kissing disease” 1
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4) Only treatment is bed rest. B.
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This note was uploaded on 03/28/2010 for the course MCRO 251 taught by Professor Lorrainecramer during the Fall '09 term at UNC.

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blood and lymphatics -Fall 2009 - /wounds 1 A...

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