Immune Disorders (notes)

Immune Disorders (notes) - mucous production), leukotrienes...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Immune Disorders With all hypersensitivity responses – the first time, we never see the hypersensitivity – it is always the second exposure Type I Anaphylactic hypersensitivity (Antigen = Allergen) – Size is important, must be small enough to diffuse into mucous. 2 things wrong in the book - they say B cells outline epithelial cells (but B cells are in follicles) Dustmites are too big to be an allergen but their feces are what we’re allergic to. Type I hypersensitivities are responses to parasites (helminthes, etc.) *Figure 18.1* Atopic – a person more genetically disposed to asthma and hay fever. - Make more IgE, have more mast cells and release granules. - Histamine (increases permeability and dilation of blood capillaries, increase of
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: mucous production), leukotrienes (prolonged contractions of smooth muscle) (histamines happen right away and leukotrienes are a delayed response) Hives fluid filled wheals from skin mast cells the mast cells are bound with IgE that responds to allergen Hay Fever upper respiratory mast cell Asthma lower respiratory mast cells cause constriction of smooth muscles in bronchial tubes Anaphylatic shock systemic dilation, causing shock. because all the capillaries are dilated so they become leaky Treatment? Induce different antibody than IgE Try to generate an IgG response (mast cells primarily bind to IgE if available) *Figure 18.3*...
View Full Document

This note was uploaded on 03/28/2010 for the course MCRO 251 taught by Professor Lorrainecramer during the Fall '09 term at UNC.

Ask a homework question - tutors are online