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Immune Disorders (notes)

Immune Disorders (notes) - mucous production...

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Immune Disorders With all hypersensitivity responses – the first time, we never see the hypersensitivity – it is always the second exposure Type I Anaphylactic hypersensitivity (Antigen = Allergen) – Size is important, must be small enough to diffuse into mucous. 2 things wrong in the book - they say B cells outline epithelial cells (but B cells are in follicles) Dustmites are too big to be an allergen but their feces are what we’re allergic to. Type I hypersensitivities are responses to parasites (helminthes, etc.) *Figure 18.1* Atopic – a person more genetically disposed to asthma and hay fever. - Make more IgE, have more mast cells and release granules. - Histamine (increases permeability and dilation of blood capillaries, increase of
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Unformatted text preview: mucous production), leukotrienes (prolonged contractions of smooth muscle) (histamines happen right away and leukotrienes are a delayed response) Hives – fluid filled wheals from skin mast cells – the mast cells are bound with IgE that responds to allergen Hay Fever – upper respiratory mast cell Asthma – lower respiratory mast cells cause constriction of smooth muscles in bronchial tubes Anaphylatic shock – systemic dilation, causing shock. – because all the capillaries are dilated so they become leaky Treatment? – Induce different antibody than IgE – Try to generate an IgG response (mast cells primarily bind to IgE if available) *Figure 18.3*...
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