EVE100_206-220_2pp

EVE100_206-220_2pp - 1 206 206 Neutral theory of molecular...

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Unformatted text preview: 2/4/10 1 206 206 Neutral theory of molecular evolution •Most new mutations are deleterious •Most of the observed molecular variation is neutral •Rate of evolution between species is equivalent to neutral mut. rate •Freq of new mutation = 1/[2N e ] = ¡xation prob •Total # new mutations/gen = 2N e μ •Rate at which mutants ¡x = 1/[2N e ] x 2N e μ = μ per generation •Independent of population size •The neutral mutation rate is a re¢ection of “functional constraint” •Polymorphism is a transient phase of divergence between species •Expect positive corr. between polymorphism and divergence Model vs. null hypothesis 207 207 Neutral theory of molecular evolution What is the expected divergence between two species that separated t generations ago and have neutral mutation rate, μ ? t Species 1 Species 2 μ μ 2/4/10 2 208 208 Neutral theory of molecular evolution What is the expected divergence between two species that separated t generations ago and have neutral mutation rate,...
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This note was uploaded on 03/29/2010 for the course EVE EVE 100 taught by Professor Davidbegun during the Winter '10 term at UC Davis.

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EVE100_206-220_2pp - 1 206 206 Neutral theory of molecular...

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