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EVE100_206-220_2pp

EVE100_206-220_2pp - Neutral theory of molecular evolution...

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2/4/10 1 206 Neutral theory of molecular evolution •Most new mutations are deleterious •Most of the observed molecular variation is neutral •Rate of evolution between species is equivalent to neutral mut. rate •Freq of new mutation = 1/[2N e ] = fixation prob •Total # new mutations/gen = 2N e μ •Rate at which mutants fix = 1/[2N e ] x 2N e μ = μ per generation •Independent of population size •The neutral mutation rate is a reflection of “functional constraint” •Polymorphism is a transient phase of divergence between species •Expect positive corr. between polymorphism and divergence Model vs. null hypothesis 207 Neutral theory of molecular evolution What is the expected divergence between two species that separated t generations ago and have neutral mutation rate, μ ? t Species 1 Species 2 μ μ
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2/4/10 2 208 Neutral theory of molecular evolution What is the expected divergence between two species that separated t generations ago and have neutral mutation rate, μ ?
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