Lecture%206

Lecture%206 - 3 subunits: CdtA, CdtB and CdtC CdtA and CdtC...

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Unformatted text preview: 3 subunits: CdtA, CdtB and CdtC CdtA and CdtC bind to an unknown receptor on the host cell surface CDT is taken up into the host cells by clathrin- coated pits Once inside, toxin leads to dsDNA breaks and cell-cycle arrest Endospore formation part of the life cycle Dormant bacterial cells endo formed inside the vegetative cells Conditions that no longer favor growth Endospore formation escape gradual death of post-stationary phase bacteria Endospores are dormant Do not have many requirements Extremely resistant to harsh conditions heat dryness Very impermeable to many chemicals Do not grow but can germinate Endospores germinate when they receive certain signals that the conditions are good for growth Spores are resting structures Little or no metabolism inside the spore Spores can survive for a very long time and then re germinate Food held at a good growth temperature after cooking endospores rapidly turn into vegetative cells Core-dehydrated cytoplasm containing DNA, ribosomes, enzymes etc. Cortex-a modified cell wall/PG layer (not as cross-linked as vegetative cell) Coat-outside of the cortex, protein layers, impermeable to most chemicals. Responsible for resistance to chemicals Induce germination Heat Good growth medium cooking Cooking kills the vegetative cells but induces the endospores to germinate Sporulation induced by nutrient starvation, changes in pH, temperature and desiccation Genera: 3 genera...
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Lecture%206 - 3 subunits: CdtA, CdtB and CdtC CdtA and CdtC...

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