BIS101 Lecture Outline v2

BIS101 Lecture Outline v2 - BIS101 S O'Neill I Genes and...

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BIS101 Genes and Gene Expression - Outline page 1 S. O'Neill I. Introduction A. Genetics B. Gene C. Central dogma D. Genotype and phenotype E. Genetic variation F. Environment- gene interaction G. Gene networks and Systems Biology H. Epigenetics/Epigenomics I. Genomics II. Mendelian Genetics (handouts #1 & 2) A. Mendel's experimental design (handout #1) B. Principle of segregation 1. Monohybrid cross 2. Test cross C. Principle of independent assortment 1. Probability a. Product rule b. Sum rule 2. Dihybrid cross 3. Calculating genetic ratios D. Mendelian genetics in humans 1. Pedigree analysis a. Recessive traits b. Dominant traits c. Two examples: handout #3
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BIS101 Genes and Gene Expression - Outline page 2 S. O'Neill III. Chromosomal Basis of Inheritance A. Mitosis and meiosis 1. Chromosome complement of eukaryotes 2. Asexual/sexual reproduction 3. Cell cycle 4. Stages of mitosis (handout #4) 5. Stages of meiosis (handout #5) 6. Genetic significance of mitosis and meiosis B. Sex-linked traits 1. Sex chromosomes a . Drosophila b. Human 2. Sex linkage a. Defined b. Reciprocal cross 3. Sex determination a . Drosophila b. Humans i. Y chromosome mechanism ii. X chromosome inactivation- dosage compensation 4. Sex-linked traits in humans a. X-linked recessive b. X-linked dominant c . Y - l i n k e d
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BIS101 Genes and Gene Expression - Outline page 3 S. O'Neill IV. Mendelian Extensions A. Multiple alleles 1 . Drosophila eye color 2. ABO blood groups B. Modifications of dominance relationships 1. Incomplete dominance a. Snapdragon flower color b. 2. Codominance C. Gene interactions (modified Mendelian ratios) 1. New phenotypes-comb shape in chickens 2. Epistasis a. recessive epistasis b. duplicate recessive epistasis -complementary gene action D. Essential genes and lethal alleles 1. Dominant lethal allele 2. Recessive lethal allele 3. Pleiotropic genes E. Penetrance and expressivity
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This note was uploaded on 03/29/2010 for the course BIO SCI 101 taught by Professor Kimsey during the Spring '10 term at UC Davis.

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BIS101 Lecture Outline v2 - BIS101 S O'Neill I Genes and...

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