Unit 6- Module 1 ProblemKEY

Unit 6- Module 1 ProblemKEY -...

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M1 U6 Problems for Contemplation-KEY 4)   Determine what the most acidic protons are on each of the following drug molecules. O OH tetrahydrocannabinol (active component in marijuana)                 O OH O ketoprofen (anti-inflammatory agent)                                       O OH N H propranolol (antihypertensive agent) 5)   Consider the 4 compounds listed and answer the questions provided C 3 H 6 O  (K a  = 5.0 x 10 -20 ) CH 3 COOH  (K a  = 1.8 x 10 -5 ) C 6 H 5 OH (K a  = 1.3 x 10 -10 ) HF   (K a  = 3.5 x 10 -4 ) a) Which is the strongest acid?   HF b) Which is the strongest base?  C 3 H 6 O c) Which has the weakest conjugate base?   HF d) Which has a conjugate base that could most effectively deprotanate C 6 H 5 OH ?  C 3 H 6 O e)  Which is a stronger base than water?  C 3 H 6 O 3)   Phenol, C 6 H 5 OH, has a pK a  in water of 10.0, but if put into pure methanol (no water present) 
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This note was uploaded on 03/29/2010 for the course CHEM 152 taught by Professor Grall during the Spring '08 term at Arizona.

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Unit 6- Module 1 ProblemKEY -...

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