CH369 exam2f98 - 1(4 pts Sarin is an organophosphorus poison that inhibits cholinesterase by interacting irreversibly with a serine residue at the

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1. (4 pts) Sarin is an organophosphorus poison that inhibits cholinesterase by interacting irreversibly with a serine residue at the active site. Indicate the functional group (you need only draw the reactive part of serine) of serine that reacts with the sarin and the product. Since sarin acts at the active site of cholinesterase, does it exhibit competitive kinetics. Explain your answer. O (CH 3 ) 2 CH—0—P F + CH 3 2. (3 pts) Regulatory enzymes in metabolic pathways are often found at the first step that is unique to that pathway. Explain why this is an effective method for regulation of metabolic pathways. 3) (4 pts) Explain why very tight binding of a substrate (or a product) to an enzyme is not desirable, but that tight binding of the transition state would be desirable. 4) (5 pts) A vitamin B6 deficiency in humans has the following symptoms: irritability, nervousness, depression and sometime convulsions. These symptoms have been attributed
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2 to decreased levels of the neurotransmitters serotonin and norepinephrine, which are synthesized from tryptophan and tyrosine respectively. Given the structures of serotinin and norepinehprine below, indicate what chemical modification was made. How is B6 involved in this reaction? Explain the clinical symptoms of B6 deficiency. 5) (5 pts) A patient suffering from methylmalonic aciduria (high levels of methylmalonic acid) has high levels of homocysteine and low levels of methionine in the blood and tissues. Folic acid levels are normal. a)
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This note was uploaded on 03/30/2010 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas at Austin.

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CH369 exam2f98 - 1(4 pts Sarin is an organophosphorus poison that inhibits cholinesterase by interacting irreversibly with a serine residue at the

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