CH369 exam2s98 - CH 369Exam 2 Spring 1998 1. (4 pts) What...

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CH 369—Exam 2 Spring 1998 1. (4 pts) What forces are involved in binding substrates and intermediates to the active sites of enzymes? 2. (5 pts) Vertebrates must obtain folic acid from the diet, whereas bacteria synthesize it from precursors including para-aminobenzoate. Sulfanilamide is a member of a class of compounds called sulfa drugs. Why is it such an effective antibacterial agent? 3) (5 pts) The procedure for testing blood glucose utilizes glucose oxidase to catalyze the following reaction: β -D-glucose + O 2 ----> D-gluconolactone + H 2 O 2 The H 2 O 2 produces a color that indicative of the amount of glucose present. Glucose oxidase is specific for the β form. Explain how this test can accurately measure TOTAL glucose ( α , β and open forms)?
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2 4) (4 pts) Why is adenylate kinase inhibited by the ATP analog shown? 5) (6 pts) A gene, ras , encodes a particular type of G protein. Several types of cancer (lung, colon, pancreas) have an mutation in this gene that produces a defective G protein. This mutant form of the G protein lacks GTPase activity. Knowing what you do about signal transduction, explain why cells carrying such a mutation are more likely to become
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This note was uploaded on 03/30/2010 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas.

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CH369 exam2s98 - CH 369Exam 2 Spring 1998 1. (4 pts) What...

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