326intro - Regulators vs conformers Physiology The science...

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The science of the function of a living organism and all its parts, including chemical and physical processes, working together to sustain the organism’s life and maintain homeostasis ... Physiology Regulators vs conformers Physiological variables in humans ! heart rate ! blood pressure ! concentration of a molecule e.g. glucose ! osmolarity ! pH ([H+]) ! temperature Human set points ! ! ! ! ! !
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Physiologic processes P maintain homeostasis (set points) P are biochemical pathways in cells or a series of steps in organ systems P are regulated P are started by a stimulus P are stopped by negative feedback P sometimes are paired (antagonistic) P are dictated by structure Cellular response to hyperglycemia : Insulin release from pancreatic β cells
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Glucose entry into cells Sugars transported Tissues found in GLUT1 Glucose, other hexoses Most GLUT2 Glucose, other hexoses Liver, kidney, intestine GLUT3 Glucose, other hexoses Neurons GLUT4 Glucose (insulin regulated) Skeletal muscle, adipose tissu> GLUT5 Fructose Intestinal epithelium
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