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LM6-1 - ReplicationofDNA StructureofDNA...

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Replication of DNA • Structure of DNA  • Replication basics (3 phases: initiation, elongation  and termination) • DNA repair by the mut system 1
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Structure of DNA (Figs. 12.2, 12.3) • Nitrogenous bases are covalently attached to  deoxyribose at the 1’ position, the 3’ and 5’  positions of the deoxyribose are involved in  attaching one nucleotide to another • Note differences in bases, sugars, nucleoside,  nucleotide 2
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Structure of DNA (Figs. 12.2, 12.3) 3 • Nucleotides on each  strand are attached to  each other via  phosphodiester bonds  linking the 5’end of one  deoxyribose to the 3’ end of  the adjacent sugar • One strand of DNA is  linked to the other via H- bonds between the bases • Strands are anti-parallel  (one strand runs 5’  3’  while the complement  runs 3’ 5’) • Bases form the rungs of a  ladder, stacking energy  adds stability
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Replication mechanisms (Figs. 12.6, 12.9) • Replication is semi-conservative: it is replicated, not  duplicated • All  DNA polymerases (DNAPs) synthesize DNA 5’   3’ • Since strands of DNA are anti-parallel, replication on the  two unwound strands has to proceed in opposite directions • Phosphodiester bond hydrolysis (2/nuc) provides energy 4
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