LM13-1 - Innate(nonspecific)immunitystructural cellular,...

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Immunology – the study of the immune system • Innate (non-specific) immunity – structural,  cellular, and molecular components are present at  birth and do not change in response to exposure to  antigens  • Adaptive (acquired, specific) immunity – T-cells  and B-cells, with help from MHC components,  change upon exposure to antigens • These systems interact to provide protection  against foreign substances 1
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Overall view of immunological systems (Fig. 28.1) • Granulocytes include polymorphonuclear leukocytes  (aka PMNs, neutrophils, “poly’s”) • Discrimination of self/non-self (i.e., foreign) is via MHC  molecules  2
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Cells of the immune system (Fig. 28.2) • Note separate lineages for  neutrophils, macrophages,  lymphocytes • Macrophages (m φ29 and  dendritic cells both derive  from monocytes  (monoblast lineage) • Neutrophils derive from  myoblasts 3
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Innate structural immunity (Fig. 28.15) • Outer skin is physical barrier,  salty, dry, acidic and is  continuously sloughed off • Dermal cells and sweat  glands secrete dermicidins  (broad-spectrum  antimicrobial 40 AA peptides)  and sweat glands secrete  lysozyme 4
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Innate structural immunity (cont.) (Fig. 28.15) Mucous membranes (cells that line regions of body directly exposed to environment) continuously flush microbes through production of mucous and ciliary action Mucous contains anti-bacterial peptides and lactoperoxidase (makes - OSCN, hypothiocyanite) Most mucosal systems sequester iron (gastro-, lactoferrin), limiting the growth of microbes 5
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Innate structural immunity (cont.)  (Fig. 28.17) • Digestive system: saliva  contains lysozyme (see Fig. at 
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