LM15 - Antibiotics and clinical immunology Selected...

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Unformatted text preview: Antibiotics and clinical immunology Selected antibiotics Anti-fungals Anti-virals Mechanisms of resistance Monoclonal Antibody production, uses ELISA 1 -lactam antibiotics (Fig. 31.5) The cillins all contain - lactam structure that inhibit transpeptidase (are analogues of D-Ala-- D-Ala) Different side chains confer different properties, ranges Resistance often develops when -lactamase (penicillinase) gene is acquired by pathogen Cephalosporins, other antibiotics also have - lactam structures 2 Vancomycin (Fig. 31.7) Large (MW>1400) antibiotic effective against G-positive organisms (not orally bioavailable) Binds to D-Ala-D-Ala residues and blocks transpeptidase as well as other steps in cell wall synthesis Resistance due to changing final D-Ala to other AA or similar structure VRE (vancomycin resistant Enterococcus ) is known to transfer resistance horizontally 3 Protein synthesis inhibitors (Figs. 31.8, 31.9) 4 Aminoglycosides (top) contain cyclohexane (blue) and aminosugars (yellow) Work by binding to 30S ribosomal subunit Resistance widespread due to enzymatic modification of the antibiotic, mutations in ribosome targets s contain 4- ring structures, bind to 30S ribosomal subunit to inhibit tRNA binding Resistance due to many factors More protein synthesis inhibitors (Figs. 31.10, 31.11)More protein synthesis inhibitors (Figs....
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LM15 - Antibiotics and clinical immunology Selected...

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