LM13-2 - Adaptiveimmunity Bcellsandantibodies...

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Adaptive immunity  • B-cells and antibodies • T-cells and T-cell receptors • MHC (major histocompatibility complex) • Macrophage-like cells bridge innate and adaptive  systems using MHC molecules 1
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Overview of adaptive responses (Fig. 28.6, 28.9) • B-cells mature in bone marrow and then circulate with  surface IgM until they encounter antigen, spending most of  their time in lymphatic structures (lymph nodes, spleen,  etc) shown right • Once antigen is encountered, they produce many kinds of  Ig’s and long-lived memory cells • Self-reactive B-cells are neutralized in bone marrow 2
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Overview of adaptive responses (Fig. 28.6, 28.9) • T-cells are produced  in bone marrow but migrate to  thymus, where they mature into several types with  different functions  • They then also circulate until they encounter antigen,  spending most of their time in same lymphatic structures  as B-cells (nodes, spleen, etc)  • Self-reactive T-cells are destroyed in thymus 3
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B-cells produce antibodies (aka Igs) Fig. 29.11)  Function of B-cells is to produce antibodies to mark foreign antigens for destruction or to neutralize antigen’s ability to function Each antigen can have many antigenic determinants or epitopes Epitopes are 3-D regions of the antigen with size:10-15 AA that make direct contact with the Ig Antibodies that bind to antigen undergo conformational changes that activate effector functions 4
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All Ig’s contain 2 identical heavy chains and 2 identical light chains Heavy and light chains each contain variable and constant regions as shown (left) The variable regions from one heavy and one light chain combine to form antigen- binding sites Fc regions are responsible for
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This note was uploaded on 03/31/2010 for the course MCB 3020 taught by Professor Ogden during the Spring '08 term at University of Florida.

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LM13-2 - Adaptiveimmunity Bcellsandantibodies...

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