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320Fall08Midterm3_key2 - BIO320Dr.Bushart MidtermExam#3...

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BIO 320 Dr. Bushart Print Name:___ Key ___________ Midterm Exam #3 12:30 PM Thursday November 6, 2008 General instructions : Read each question carefully and don’t hesitate to ask if a question seems unclear. Trying to provide an answer for every question is advantageous; you will not be penalized for guessing. Write a clear concise answer for each question. Some questions may have more than one possible answer but require you to defend your choice. The questions have specific answers, although for some, more than one answer is possible. If possible, answer each question in the space provided, but if needed, continue on the back. If you use a drawing as part of your answer, be sure to also include appropriate labeling and/or a short written explanation. Use pen if you want a chance for a regrade. This exam is 4 pages long and worth a total of 100 points (the points for each section/question are noted in parentheses throughout). To receive full credit you must clearly and fully answer the question being asked. Partial credit may be given in 0.5 point increments. Be sure you include clear explanations in your response. Make sure your response answers the question being asked! 1. Without altering the total amount of actin present, what are two different changes that individually would encourage the elongation of actin filaments? Your answer should either address changes to subunits or involve accessory proteins. Generally explain how each change would promote filament growth. a. (6 points) Any of: activation of profilin, inhibition of thymosin, slower ATP hydrolysis, activation of formin, etc. Profilin and formin both improve the addition of subunits to filaments. Slower ATP hydrolysis may allow for growth at minus ends by keeping them T-form. Inhibiting thymosin would free more subunits, increasing the effective concentration of subunits. Gelsolin and ARPs would not be a good choice (partial credit) since they impact nucleation, but not the actual likelihood of elongation. b. (6 points) 2. (8 points) Myosin V is a typical myosin family member used to deliver certain RNAs to the daughter cell of budding yeast. Describe (1) the filament type, (2) the orientation, and
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