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012609%20Section%2003%20No%20Answer

012609%20Section%2003%20No%20Answer - Patrick Corpuz...

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Patrick Corpuz [email protected] A01: Mon. 8-8:50 Center 207 01/26/09 OH: Fri. 8-8:50 Leichtag Lobby A04: Wed. 8-8:50 Center 220 WEEK 3 I. Neuromuscular Junction (NMJ) a. Receptors respond to ________ => therefore referred to as ________ i. Sensitive to nicotine => therefore referred to as nicotinic, synapse to muscle: hence name of receptors are ________ ii. Ligand-gated ion channels requires 2Ach (Ach not specific to type of channels, type of channels specific to type of synapse, IPSP or EPSP) b. Steps to NMJ Function i. ________ AP hits presynaptic terminal ii. Depolarization of voltage-gated ________ channels (P/Q) iii. Calcium ________ presynaptic terminal iv. Triggers vesicle exocytosis containing Ach v. Ach diffuses across the synapse to bind to n M AchR vi. Excitatory Postsynaptic Potential (EPSP), Endplate potential (EPP) for muscles vii. EPSP is a ________ potential (not all or nothing), increase Ach = stronger EPP 1. Muscle AP? small EPP no AP 2. Enough Ach big EPP V T results in MAP c. Termination of signal via Degradation, Diffusion, Recycling i. Ca++ diffuses away from or pumped out ii. Ach dissociates from receptors iii. Ach diffuses away from zone of post-synaptic receptors iv. Ach broken down by ________________ to form Choline+Acetate v. Recycle 1. Choline uptake via Na+/Choline symporters 2. In terminal: Choline + Acetyl-CoA forms Ach using enzyme ________________ 3. Entrance back into vesicles ________________ d. Figure: Summary of NMJ
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Patrick Corpuz [email protected] A01: Mon. 8-8:50 Center 207 01/26/09 OH: Fri. 8-8:50 Leichtag Lobby A04: Wed. 8-8:50 Center 220 e. Inhibition of NMJ i. IPSP 1. P K+ 2. P Cl- ii. ________ – Binds to Ach receptors and prevents binding of Ach, known as an antagonist 1. Effectively paralyzing muscle 2. Death due to inhibition to respiratory muscles 3. K+ build up in veins, high concentration results in depolarization of heart, unable to restore resting state and paralysis iii. ________________ – NMJ autoimmune disease 1. Weakness in muscle and eventually paralysis 2. Generation of Abs against AchR II. Other Synapses a. Convergence (not in muscle) vs Divergence Figure: b. Summation: Temporal (Time) vs Spatial Figure: III. Orientation (FYI) a. Superior – closer to head b. Inferior – away from head c. Anterior (ventral) – closer to chest d. Posterior (dorsal) – closer to back e. Medial – closer to midline f. Lateral – away from midline g.
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