BIPN100 Sheet 3

BIPN100 Sheet 3 - PatriciaPepa OH:Friday111150AMCafRoma...

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Patricia Pepa OH: Friday 11-1150AM Café Roma Handout 3 I. 2 Major types of postsynaptic receptors     a. Ionotropic -receptor themselves are the ion channel b. Metabotropic -acts through 2 nd  messenger system i. ____________ coupled receptors 1. Off state : G protein has G , G , and G  sections. G  section is α β α α   bound to GDP. 2. On state : Ligand binds conformational change GDP  exchanges with ______ now activated alter enzyme activity  which turns on 2 nd  messengers usually activating protein kinases 3. Termination : intrinsic GTPase activity- hydrolyze GTP to GDP.  Slow. a. What would happen if you inhibit GTPase? i. _________________________________________ _________________________________________ ________ ii. Main 2 nd  Messengers 1. cAMP (Cyclic AMP)-activates protein kinases 2. Ca2+- alters enzyme activity 3. PIP2  makes 2 messengers a. IP3 -increases intracellular Ca by opening Ca Channels b. DAG -activates protein kinases II. Ligands involved in cell’s long-distance communication     a. Neurocrines -Electrical signal travels down neuron, and is translated to a  chemical signal. i. Neurotransmitters -chemicals secreted by neurons and go to target cell ii. Neuromodulators -acts more slowly as an autocrine or paracrine signal iii. Neurohormones -hormones released by neurons into blood b. Hormones -secreted by endocrine glands or cells into blood III. Neurotransmitters (don’t be overwhelmed, focus on bolded stuff)     NT Type Receptor Locations Effects Agonists/Antagoni sts Acetylcholi ne  (ACh) nAChR (Ionotropic) Skeletal  muscles, ANS,  CNS Excitatory : Opens N a+/ K+ channel   Muscle  contraction, interneuron  signaling Agonist - Nicotine Antagonist –  Bungarotoxin mAChR (metabotropi c) Smooth/cardiac  muscle, glands  ( Parasympatheti Inhibitory : Heart  ( opens K+chnls ) Excitatory: Glands, GI,  Antagonist -  Atropine
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Patricia Pepa OH: Friday 11-1150AM Café Roma C h e m i c a l c  Input) CNS bladder, bronchioles  (via vagus nerves) Amines Norepinep hrine  (NE)  Epinephrin e  (E) Made from  Tyrosine Main NTs 
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This note was uploaded on 03/31/2010 for the course BIMM bimm 100 taught by Professor Dr.sato during the Winter '08 term at UCSD.

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BIPN100 Sheet 3 - PatriciaPepa OH:Friday111150AMCafRoma...

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