BIPN100 Sheet 3 Answers

BIPN100 Sheet 3 Answers - PatriciaPepa OH: Handout3 a b i 1...

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Patricia Pepa OH: Friday 11-1150AM Caf é  Roma Handout 3 I. 2 Major types of postsynaptic receptors     a. Ionotropic -receptor themselves are the ion channel b. Metabotropic -acts through 2 nd  messenger system i. G-protein coupled receptors 1. Off state: G protein has G , G , and G  sections. G  section is α β α α   bound to GDP. 2. On state: Ligand binds conformational change GDP exchanges  with GTP now activated alter enzyme activity which turns on  2 nd  messengers usually activating protein kinases 3. Termination: intrinsic GTPase activity- hydrolyze GTP to GDP.  Slow. a. What would happen if you inhibit GTPase? i. G protein would continue to activate and would  have no method of turning off. Too much  stimulation.. ii. Main 2 nd  Messengers 1. cAMP(Cyclic AMP)-activates protein kinases 2. Ca2+-alters enzyme activity 3. PIP2 makes 2 messengers a. IP3-increases intracellular Ca by opening Ca Channels b. DAG-activates protein kinases II. Ligands involved in cell’s long-distance communication     a. Neurocrines -Electrical signal travels down neuron, and is translated to a  chemical signal. i. Neurotransmitters -chemicals secreted by neurons and go to target cell ii. Neuromodulators -acts more slowly as an autocrine or paracrine signal iii. Neurohormones -hormones released by neurons into blood b. Hormones -secreted by endocrine glands or cells into blood III. Neurotransmitters NT Type Receptor Location s Effects Agonists/Antagonists Acetylcholin e  (ACh) nAChR (Ionotropic) Skeletal  muscles,  ANS,  CNS Excitatory : Opens  N a+/K+ channel  Muscle contraction,  interneuron signaling Agonist - Nicotine Antagonist –  Curare & Bungarotoxin mAChR (metabotropic) Smooth/c ardiac  Inhibitory : Heart  ( opens K+chnls ) Antagonist - Atropine
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Patricia Pepa OH: Friday 11-1150AM Caf é  Roma C h e m i c a l muscle,  glands  ( Parasy mpatheti c  Input)  CNS Excitatory: Glands,  GI, bladder,  bronchioles  (via vagus nerves) Amines Norepinephri ne  (NE) &  Epinephrine  (E) Made from  Tyrosine Main NTs for  sympathetic  nervous  system (Catecholami ne) Adrenergic -1 (NE > E) α (metabotropic) Blood  vessels,  pupil,  uterus Excitatory: contraction  (vasoconstriction,  pupil dilation) Adrenergic -2 (NE > E) α (metabotropic) Presynap tic 
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