9 - Mobile DNA - transposable elements Discovery of...

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Mobile DNA - transposable elements • Discovery of transposons • Transposable elements • DNA transposons • Retrotransposons viral-like (LTRs) • poly-A (non-LTRs) ! LINES ! SINES • Roles in evolution Transposable elements (TEs) - non-functional DNA? • TEs - long stretches of DNA that can move around the genome of a cell (or organism) • Genomes of higher organisms “cluttered” with numerous copies of these elements • TEs can control gene activity • TEs have significant influence of evolution of genomes Mobile DNA Elements = Transposable Elements = “jumping genes”
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Two Types of Transposition (source: Molecular Biology of the Gene, 5th Ed.) copy & paste
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(source: Molecular Biology of the Gene, 5th Ed.) Three families of Transposable Elements 1. 2. 3. (aka non-LTR retrotransposons) (aka LTR retrotransposons) 1. DNA transposons • Length of direct repeat characteristic of IS type • Sequence of direct repeat depends on target site - direct repeat due to insertion process
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9 - Mobile DNA - transposable elements Discovery of...

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