12.2 - hyperacetylated state Assembly of RNA POL II...

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chromodomain chromoshadow domain Higher eukaryotes express proteins with domains (chromodomains) that bind to histone tails that are methylated at specific lysines • Example: heterochromatin protein 1 (HP1) Many of these proteins also contain a second domain called a chromoshadow domain that binds to other chromoshadow domains • Example: HP1 associates with HP1 and with HMT - this facilitates heterochromatin formation and spreading
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TFIID - multimeric protein consisting of: • TATA box-binding protein (TBP) • TBP-associated factors (TAFs) - 13 additional factors • bromodomains - bind to acetylated histone tails - help it to remain associated with transcriptionally active chromatin (euchromatin) • has histone acetylase activity - maintains chromatin in
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Unformatted text preview: hyperacetylated state Assembly of RNA POL II Pre-initiation complex bromodomains Repressors can direct histone deacetylation and methylation at specific sites: 1. DNA binding domain 2. Repressor domain 3. Recruitment of deacetylases general transcription factors cant bind to TATA box co-repressors Upstream regulatory sequence (URS) Some co-repressor subunits also have methyl transferase activity Activators can direct histone(hyper)acetylation at specific sites: 1. DNA binding domain 2. Activator domain 3. Recruitment of acetylases facilitate access of general transcription factors required for initiation co-activators Upstream activating sequence (UAS) Some co-activator subunits also have methylase activity...
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12.2 - hyperacetylated state Assembly of RNA POL II...

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