17 - Lecture 17 Translation: Stepwise Synthesis of Proteins...

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Translation: Stepwise Synthesis of Proteins on Ribosomes Lecture 17 Stepwise synthesis of proteins on ribosomes 1. ribosomal subunits 2. initiation 3. elongation 4. termination 5. translation efficiency
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Translation has 3 stages: Initiation, Elongation and Termination Various factors are involved at each stage : e ukaryotic I nitiation F actors: eIFs eIF1, eIF2 etc. E longation F actors: EFs EF1 ! e ukaryotic R elease F actors: eRFs eRF1, eRF3 etc.
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Step 1: Initiation Start codon is usually AUG • Met-tRNA i Met is used to initiate protein synthesis • Met-tRNA Met is used to add Methionine residues within the polypeptide chain • Met-tRNA i Met and Met-tRNA Met are both synthesized by the same aminoacyl-tRNA synthetase (MetRS) but bind distinct sites on the ribosome
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rRNAs proteins subunits assembled ribosome Eukaryotic Ribosomes The large and small ribosomal subunits are kept apart by Initiation Factors ( eIF s) and have to assemble into the complete ribosome on the mRNA
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17 - Lecture 17 Translation: Stepwise Synthesis of Proteins...

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