lecture 10

lecture 10 - Chapter 5! Antigen Recognition by T...

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Chapter 5 Antigen Recognition by T Lymphocytes MHC MMI 188 2010 Human Immune System Lecture 5 Chris Bowlus [email protected]
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T cell/MHC Interactions
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MHC Class I Peptide Loading
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MHC Class I Antigen Processing Cytoplasmic, intracellular pathogens 1. Degraded by proteasome 2. Peptide transported to ER 3. Binding to MHC class I in ER 4. Transport to cell surface
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MHC Class I Caveats Most peptides do not bind to MHC Non-infected cells display self antigen Do not illicit an immune response “tolerance” Break in tolerance results in autoimmunity
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MHC Class II Antigen Processing Extracellular pathogens 1. Endocytosis 2. Degradation in phagosome 3. Binding to MHC class II 4. Transport to cell surface
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MHC Class II Presentation
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MHC Class II Chaperones Invariant Chain Directs MHC to endocytic vesicles MHC class II compartment (MIIC) CLIP Product of Invariant Chain cleavage Blocks binding of peptide Removal is aided by interaction of MHC with HLA- DM HLA-DM MHC class II molecule Does not bind peptide or appear on cell surface
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Figure 3-22 *Activated T cells Differential Expression of MHC Molecules
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Major Histocompatibility Complex Major versus minor Histo (tissue) compatibility for transplantation Complex of genes
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This note was uploaded on 04/02/2010 for the course MMI 188 taught by Professor Josetorres during the Winter '10 term at UC Davis.

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lecture 10 - Chapter 5! Antigen Recognition by T...

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