4principlesadaptive

4principlesadaptive - Principles of Adaptive Immunity...

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Principles of Adaptive Immunity Lecture 4 Chapter 3 MMI 188 Human Immunology José V. Torres, Ph.D. Professor Medical Microbiology and Immunology School of Medicine University of California at Davis jvtorres@ucdavis.edu
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Adaptive Immune Response – Adaptive Immunity Third line of defense Two types of Lymphocytes: B cell T cell More focused and forceful response to any pathogen Innate immunity recognizes structures shared by many pathogens Adaptive immunity recognizes pathogens by just one molecular type of receptor in B cells and T cells Infinite versions – Millions of B and T cell receptors with different binding sites Immunological memory
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Recognition molecules of adaptive immunity Structure of: - Surface Immunoglobulin (B cell receptor) - Antibody (immunoglobulin secreted by plasma cells) - T cell Receptor antigen receptors
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Immunoglobulins bind to a larger variety of chemical structures than T cell receptors Antibody specificity
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Diversity of Immunoglobulins and T cell receptors Somatic Recombination - gene rearrangement -breaking and splicing Gene segments: Immunoglobulin heavy chain and T cell receptor β chain V, D and J Immunoglobulin light chain and T cell receptor α chain V and J
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produces diversity Clonal Selection Clonal Expansion Primary Immune Response
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This note was uploaded on 04/02/2010 for the course MMI 188 taught by Professor Josetorres during the Winter '10 term at UC Davis.

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4principlesadaptive - Principles of Adaptive Immunity...

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